Early F-FDOPA PET/CT imaging after carbidopa premedication as a valuable diagnostic option in patients with insulinoma.
Fiche publication
Date publication
janvier 2019
Journal
European journal of nuclear medicine and molecular imaging
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BACHELLIER Philippe, Pr IMPERIALE Alessio
Tous les auteurs :
Leroy-Freschini B, Amodru V, Addeo P, Sebag F, Vix M, Brunaud L, Klein M, Bahougne T, Bachellier P, Castinetti F, Goichot B, Chevalier E, Taieb D, Imperiale A
Lien Pubmed
Résumé
Data on the diagnostic value of F-FDOPA PET/CT in patients with insulinoma are limited and are focused on small patient populations explored using different PET/CT protocols and the inconsistent use of carbidopa premedication. The aim of this study was to improve the current knowledge about the diagnostic value of F-FDOPA PET/CT combined with oral carbidopa premedication and early pancreatic imaging for tumour localization in patients with insulinoma-related hyperinsulinaemic hypoglycaemia (HH). The relationships among F-FDOPA quantitative uptake parameters, insulin secretion and tumour pathological features were also investigated.
Mots clés
18F-FDOPA, Carbidopa, Hyperinsulinism, Insulinoma, Neuroendocrine tumours, PET
Référence
Eur. J. Nucl. Med. Mol. Imaging. 2019 Jan 7;: