NUT carcinoma in children and adults: A multicenter retrospective study.
Fiche publication
Date publication
juin 2017
Journal
Pediatric blood & cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHASTAGNER Pascal
Tous les auteurs :
Lemelle L, Pierron G, Fréneaux P, Huybrechts S, Spiegel A, Plantaz D, Julieron M, Dumoucel S, Italiano A, Millot F, Le Tourneau C, Leverger G, Chastagner P, Carton M, Orbach D
Lien Pubmed
Résumé
Nuclear protein of the testis (NUT) carcinoma (formerly NUT midline carcinoma) is an aggressive tumor defined by the presence of NUT rearrangement with a poor prognosis. This rare cancer is underdiagnosed and poorly treated.
Mots clés
NUT carcinoma, NUT gene, NUT midline carcinoma, bromodomain and extraterminal (BET) protein, chemotherapy, histone deacetylase
Référence
Pediatr Blood Cancer. 2017 Jun;: