Labile glycated haemoglobin and carbamylated haemoglobin are still critical points for HbA1c measurement.
Fiche publication
Date publication
juin 2017
Journal
Biochemia medica
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe
Tous les auteurs :
Desmons A, Jaisson S, Leroy N, Gillery P, Guillard E
Lien Pubmed
Résumé
Haemoglobin A1c (HbA1c) is a key analyte for the monitoring of glycemic balance in diabetic patients and is used for diabetes diagnosis in many countries. The potential interference of carbamylated haemoglobin (cHb) and labile glycated haemoglobin (LA1c) on HbA1c assays must remain a matter of vigilance. Such a situation has occurred in our laboratory with a kit replacement on the Bio-Rad Variant™ II testing system, a cation-exchange high performance liquid chromatography (HPLC) system. With this method, LA1c and cHb coeluted in a same peak which may have different consequences on HbA1c values.
Mots clés
HbA1c, analytical interference, carbamylated haemoglobin, labile glycated haemoglobin
Référence
Biochem Med (Zagreb). 2017 Jun;27(2):378-386