Changes in dorsolateral prefrontal connectivity after rTMS in treatment-resistant depression: a brain perfusion SPECT study.
Fiche publication
Date publication
juin 2017
Journal
European journal of nuclear medicine and molecular imaging
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VERGER Antoine
Tous les auteurs :
Richieri R, Jouvenoz D, Verger A, Fiat P, Boyer L, Lançon C, Guedj E
Lien Pubmed
Résumé
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and safe alternative to electroconvulsive therapy for treatment-resistant depression (TRD). After rTMS, changes in brain SPECT perfusion have been remotely identified within medial temporal limbic areas, while no local effects have been found within the left dorsolateral prefrontal cortex (DLPFC)-i.e. under the coil. Functional changes in connectivity may underlie these remote effects. Interestingly, functional connectivity has been recently investigated using perfusion SPECT, and abnormalities identified in TRD patients. The aim of the present study is to evaluate perfusion and connectivity SPECT changes in TRD patients after rTMS of the left DLPFC. We hypothesize that changes in DLPFC networks may explain remote hypoperfusions found after rTMS.
Mots clés
Depressive Disorder, Treatment-Resistant, diagnostic imaging, Female, Humans, Male, Middle Aged, Nerve Net, diagnostic imaging, Perfusion Imaging, Prefrontal Cortex, diagnostic imaging, Retrospective Studies, Tomography, Emission-Computed, Single-Photon, Transcranial Magnetic Stimulation
Référence
Eur. J. Nucl. Med. Mol. Imaging. 2017 Jun;44(6):1051-1055