An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy.
Fiche publication
Date publication
juin 2017
Journal
Trends in pharmacological sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MULLER Sylviane
Tous les auteurs :
Bonam SR, Partidos CD, Halmuthur SKM, Muller S
Lien Pubmed
Résumé
Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In addition, they reduce antigen concentration and the number of immunizations required for protective efficacy, therefore contributing to making vaccines more cost effective. Our better understanding of the molecular mechanisms of immune recognition and protection has led research efforts to develop new adjuvants that are currently at various stages of development or clinical evaluation. In this review, we focus mainly on several of these promising adjuvants, and summarize recent work conducted in various laboratories to develop novel lipid-containing adjuvants.
Mots clés
CpG ODNs, QS-21, delivery systems, lipopeptides, new adjuvants, patents, vaccines
Référence
Trends Pharmacol. Sci.. 2017 Jun;: