Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation.
Fiche publication
Date publication
juillet 2017
Journal
Stem cell research & therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BENSOUSSAN Danièle, Pr MAGDALOU Jacques, Dr REPPEL Loïc
Tous les auteurs :
Avercenc-Léger L, Guerci P, Virion JM, Cauchois G, Hupont S, Rahouadj R, Magdalou J, Stoltz JF, Bensoussan D, Huselstein C, Reppel L
Lien Pubmed
Résumé
The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available for MSC isolated from Wharton's jelly (WJ-MSC). We initiated a study to identify whether obstetric factors influenced MSC properties. We aimed to evaluate the correlation between a large number of obstetric factors collected during pregnancy and until peripartum (related to the mother, the labor and delivery, and the newborn) with WJ-MSC proliferation and chondrogenic differentiation parameters.
Mots clés
Chondrogenic differentiation, Mesenchymal stromal cells, Obstetric factors, Proliferation, Umbilical cord, Wharton’s jelly
Référence
Stem Cell Res Ther. 2017 Jul;8(1):161