Protecting group-free radical decarboxylation of bile acids: Synthesis of novel steroidal substituted maleic anhydrides and maleimides and evaluation of their cytotoxicity on C6 rat glioma cells.
Fiche publication
Date publication
juillet 2017
Journal
Steroids
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LIZARD Gérard
Tous les auteurs :
Samadi M, Nury T, Khalafi-Nezhad A, Lizard G
Lien Pubmed
Résumé
We report the first Barton radical decarboxylation of unprotected bile acids via in situ irradiation of their thiohydroxamic esters in the presence of citraconic anhydride and citracoimide, leading to the synthesis a series of steroidal maleic anhydrides and maleimides as novel hybrid bile acids. The cytotoxic activities were evaluated on C6 rat glioma cells.
Mots clés
Barton decarboxylation, Bile acids, C6 rat glioma cells, Cytotoxic activity, Steroidal maleic anhydrides, Steroidal maleimide
Référence
Steroids. 2017 Jul;: