Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome.
Fiche publication
Date publication
juillet 2017
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ANTONICELLI Franck
Tous les auteurs :
Giusti D, Gatouillat G, Le Jan S, Plée J, Bernard P, Antonicelli F, Pham BN
Lien Pubmed
Résumé
Bullous Pemphigoid (BP) is an inflammatory rare autoimmune bullous dermatosis, which outcome cannot be predicted through clinical investigations. Eosinophils are the main immune infiltrated cells in BP. However, the release of Major Basic Protein (MBP), Eosinophil Derived Neurotoxin (EDN), and Eosinophil Cationic Protein (ECP) upon eosinophil activation has still not been evaluated with respect to BP development. MBP, EDN and ECP were measured by ELISA in serum (n = 61) and blister fluid (n = 20) of patients with BP at baseline, and in serum after 2 months of treatment (n = 41). Eosinophil activation in BP patients was illustrated at baseline by significantly higher MBP, EDN and ECP serum concentrations as compared with control subjects (n = 20), but without distinction according to disease severity or outcome. EDN and ECP values were even higher in the blister fluids (P < 0.01 and P < 0.05, respectively), whereas MBP values were lower (P < 0.001). ECP serum concentration decreased after 60 days of treatment in BP patients with ongoing remission but not in patients who later relapsed (P < 0.05). A reduction of at least 12.8 ng/mL in ECP concentrations provided a positive predictive value for remission of 81%, showing that ECP serum variation could be a useful biomarker stratifying BP patients at risk of relapse.
Mots clés
Aged, Aged, 80 and over, Anti-Inflammatory Agents, therapeutic use, Biomarkers, blood, Case-Control Studies, Cell Movement, drug effects, Clobetasol, therapeutic use, Eosinophil Cationic Protein, blood, Eosinophil Major Basic Protein, blood, Eosinophil-Derived Neurotoxin, blood, Eosinophils, drug effects, Female, Gene Expression, Humans, Male, Pemphigoid, Bullous, diagnosis, Predictive Value of Tests, Prognosis, Prospective Studies, Recurrence, Remission Induction, Severity of Illness Index, Survival Analysis, Treatment Outcome
Référence
Sci Rep. 2017 Jul;7(1):4833