CD44 Orchestrates Metastatic Teamwork.

Fiche publication


Date publication

décembre 2018

Journal

Developmental cell

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GOETZ Jacky


Tous les auteurs :
Chaffer CL, Goetz JG

Résumé

Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential.

Référence

Dev. Cell. 2018 Dec 17;47(6):691-693