Optimization of liposomal indocyanine green for imaging of the urinary pathways and a proof of concept in a pig model.
Fiche publication
Date publication
août 2017
Journal
Surgical endoscopy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARESCAUX Jacques
Tous les auteurs :
Friedman-Levi Y, Larush L, Diana M, Marchegiani F, Marescaux J, Goder N, Lahat G, Klausner J, Eyal S, Magdassi S, Nizri E
Lien Pubmed
Résumé
Iatrogenic ureteral injury is an increasing concern in the laparoscopic era, affecting both patient morbidity and costs. Current techniques enabling intraoperative ureteral identification require invasive procedures or radiations. Our aim was to develop a real-time, non-invasive, radiation-free method to visualize ureters, based on near-infrared (NIR) imaging. For this purpose, we interfered with the biliary excretion pathway of the indocyanine green (ICG) fluorophore by loading it into liposomes, enabling renal excretion. In this work, we studied various parameters influencing ureteral imaging.
Mots clés
Indocyanine green, Liposomes, Minimal invasive surgery, Ureteral injury
Référence
Surg Endosc. 2017 Aug;: