Investigation of optimal physical parameters for precise proton irradiation of orthotopic tumors in small animals.
Fiche publication
Date publication
décembre 2018
Journal
International journal of radiation oncology, biology, physics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FINCK Christian
Tous les auteurs :
Vanstalle M, Constanzo J, Finck C
Lien Pubmed
Résumé
The lack of evidence of biomarkers identifying patients that would benefit from proton therapy has driven the emergence of preclinical proton irradiation platforms using advanced small-animal models to mimic clinical therapeutic conditions. This study aims to determine the optimal physical parameters of the proton beam with a high radiation targeting accuracy, since small-animal tumors can reach millimetric dimensions at a maximum depth of about 2 cm.
Référence
Int. J. Radiat. Oncol. Biol. Phys.. 2018 Dec 1;: