Computational discovery of direct associations between GO terms and protein domains.
Fiche publication
Date publication
novembre 2018
Journal
BMC bioinformatics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DEVIGNES Marie-Dominique
Tous les auteurs :
Alborzi SZ, Ritchie DW, Devignes MD
Lien Pubmed
Résumé
Families of related proteins and their different functions may be described systematically using common classifications and ontologies such as Pfam and GO (Gene Ontology), for example. However, many proteins consist of multiple domains, and each domain, or some combination of domains, can be responsible for a particular molecular function. Therefore, identifying which domains should be associated with a specific function is a non-trivial task.
Mots clés
Gene ontology, Protein domain, Protein function, Protein structure, Vector similarity
Référence
BMC Bioinformatics. 2018 Nov 20;19(Suppl 14):413