Sponge like microparticles for drug delivery and cosmeto-textile use: Formulation and human skin penetration.
Fiche publication
Date publication
septembre 2017
Journal
International journal of pharmaceutics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HUMBERT Philippe
Tous les auteurs :
Zafar N, Robin S, Viennet C, Humbert P, Valour JP, Agusti G, Fessi H, Elaissari A
Lien Pubmed
Résumé
This unique work is targeted to achieve three main goals: i) to enhance the aqueous solubility of three specifically selected hydrophobic active agents, ii) to prepare such polymeric biodegradable microparticles which can encapsulate actives-cyclodextrin complexes and iii) to functionalize a polyamide base textile with active loaded microparticles and active-cyclodextrin loaded microparticles. To achieve this objective, biodegradable cationic microparticles were prepared via double emulsion solvent evaporation process and were loaded with hydroxypropyl-beta-cyclodextrin based complexes of Indomethacin, α-tocopheroland Lauryl Isoquinolinium Bromide during the formulation process. Inclusion complex based particles were evaluated for their morphology, size distribution, zeta potential, skin penetrationaptitude and adsorption onto a selected textile.It was observed that active-cyclodextrin complex encapsulation do not affect the morphology, size and zeta potential of the microparticles as well as adsorption of the microparticles onto textile remains unaltered. However such active-cyclodextrin complex encapsulated particles provided the enhancement in the aqueous solubility of hydrophobic agents and also provided prolonged release formulations.
Mots clés
Anti-hair growth, Anti-inflammation, Antioxidant, Cosmetology, Double emulsion-solvent evaporation, Eudragit(®) RS100, Hydroxypropyl-beta-cyclodextrin (HPβCD), Indomethacin (IMC), Lauryl Isoquinolinium Bromide (LIB), Zeta CAD, α-tocopherol (Vit. E)
Référence
Int J Pharm. 2017 Sep;: