Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails.
Fiche publication
Date publication
novembre 2017
Journal
Retrovirology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr RUFF Marc
Tous les auteurs :
Benleulmi MS, Matysiak J, Robert X, Miskey C, Mauro E, Lapaillerie D, Lesbats P, Chaignepain S, Henriquez DR, Calmels C, Oladosu O, Thierry E, Leon O, Lavigne M, Andreola ML, Delelis O, Ivics Z, Ruff M, Gouet P, Parissi V
Lien Pubmed
Résumé
Stable insertion of the retroviral DNA genome into host chromatin requires the functional association between the intasome (integrase·viral DNA complex) and the nucleosome. The data from the literature suggest that direct protein-protein contacts between integrase and histones may be involved in anchoring the intasome to the nucleosome. Since histone tails are candidates for interactions with the incoming intasomes we have investigated whether they could participate in modulating the nucleosomal integration process.
Mots clés
Chromatine, HIV-1, Histone tails, Integrase, Nucleosome, Retroviral integration
Référence
Retrovirology. 2017 Nov 28;14(1):54