The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses.
Fiche publication
Date publication
novembre 2018
Journal
Cellular and molecular life sciences : CMLS
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas, Dr VERRIER Eloi
Tous les auteurs :
Eller C, Heydmann L, Colpitts CC, Verrier ER, Schuster C, Baumert TF
Lien Pubmed
Résumé
Chronic hepatitis B, C and D virus (HBV, HCV and HDV) infections are a major cause of liver disease and cancer worldwide. Despite employing distinct replication strategies, the three viruses are exclusively hepatotropic, and therefore depend on hepatocyte-specific host factors. The sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes that mediates the transport of bile acids, plays a key role in HBV and HDV entry into hepatocytes. Recently, NTCP has been shown to modulate HCV infection of hepatocytes by regulating innate antiviral immune responses in the liver. Here, we review the current knowledge of the functional role and the molecular and cellular biology of NTCP in the life cycle of the three major hepatotropic viruses, highlight the impact of NTCP as an antiviral target and discuss future avenues of research.
Mots clés
Hepacivirus, genetics, Hepatitis B, genetics, Hepatitis B virus, genetics, Hepatitis C, genetics, Hepatitis D, genetics, Hepatitis Delta Virus, genetics, Hepatocytes, pathology, Humans, Life Cycle Stages, genetics, Organic Anion Transporters, Sodium-Dependent, genetics, Symporters, genetics, Virus Internalization
Référence
Cell. Mol. Life Sci.. 2018 Nov;75(21):3895-3905