Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.
Fiche publication
Date publication
décembre 2017
Journal
Journal of experimental & clinical cancer research : CR
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BRONNER Christian, Dr HAMICHE Ali, Pr MELY Yves, Dr RICHERT Ludovic, Dr MOUSLI Marc
Tous les auteurs :
Ashraf W, Bronner C, Zaayter L, Ahmad T, Richert L, Alhosin M, Ibrahim A, Hamiche A, Mely Y, Mousli M
Lien Pubmed
Résumé
The nuclear epigenetic integrator UHRF1 is known to play a key role with DNMT1 in maintaining the DNA methylation patterns during cell division. Among UHRF1 partners, TIP60 takes part in epigenetic regulations through its acetyltransferase activity. Both proteins are involved in multiple cellular functions such as chromatin remodeling, DNA damage repair and regulation of stability and activity of other proteins. The aim of this work was to investigate the interaction between UHRF1 and TIP60 in order to elucidate the dialogue between these two proteins.
Mots clés
Cancer, Cell cycle, Epigenetics, Fluorescence lifetime imaging microscopy (FLIM), Fluorescence resonance energy transfer (FRET), Protein-protein interaction, TIP60, UHRF1
Référence
J. Exp. Clin. Cancer Res.. 2017 12 21;36(1):188