Myogenic Progenitor Cells Exhibit Type I Interferon-Driven Proangiogenic Properties and Molecular Signature During Juvenile Dermatomyositis.
Fiche publication
Date publication
janvier 2018
Journal
Arthritis & rheumatology (Hoboken, N.J.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHELLY Jamel
Tous les auteurs :
Gitiaux C, Latroche C, Weiss-Gayet M, Rodero MP, Duffy D, Bader-Meunier B, Glorion C, Nusbaum P, Bodemer C, Mouchiroud G, Chelly J, Germain S, Desguerre I, Chazaud B
Lien Pubmed
Résumé
Juvenile dermatomyositis (JDM) is an inflammatory pediatric myopathy characterized by focal capillary loss in muscle, followed by progressive recovery upon adequate treatment with immunomodulating drugs, although some patients remain refractory to treatment. While the underlying mechanism of capillary depletion remains uncertain, recent studies have identified an up-regulation of type I interferon (IFN) expression specific to JDM. Given that myogenic precursor cells (MPCs) exert proangiogenic activity during normal skeletal muscle regeneration, we hypothesized that they may also modulate vascular remodeling/angiogenesis during JDM. The aim of this study was to investigate that hypothesis.
Mots clés
Cell Culture Techniques, Cell Migration Assays, Cell Proliferation, Child, Child, Preschool, Dermatomyositis, metabolism, Endothelial Cells, metabolism, Female, Gene Expression Profiling, methods, Humans, Immunohistochemistry, Interferon Type I, metabolism, Male, Muscle, Skeletal, metabolism, Muscular Dystrophy, Duchenne, pathology, Neovascularization, Pathologic, metabolism, Stem Cells, metabolism