Morphofunctional Organization of the Connections From the Medial and Intermediate Parts of the Central Nucleus of the Amygdala Into Distinct Divisions of the Lateral Hypothalamic Area in the Rat.

Fiche publication


Date publication

janvier 2018

Journal

Frontiers in neurology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FELLMANN Dominique


Tous les auteurs :
Barbier M, Fellmann D, Risold PY

Résumé

Projections from the central nucleus of the amygdala (CEA) into the lateral hypothalamic area (LHA) show a very complex pattern. After injection of an anterograde tracer ( leucoagglutinin-PHAL) into the medial and intermediate parts of the CEA, we observed that labeled axons converged onto the caudal lateral LHA but provided distinct patterns in rostral tuberal regions. These projections were compared to that of neurons containing the peptides "melanin-concentrating hormone" (MCH) or hypocretin (Hcrt). Because the distribution of these neurons is stereotyped, it was possible to characterize distinct divisions into the LHA. Some of them in the rostral tuberal LHA [the dorsal (LHAd) and suprafornical regions (LHAs)] received a distinct innervation by projections that originated from neurons in respectively anterior or posterior regions of the medial part (CEAm) or from the intermediate part (CEAi) of the central nucleus. Therefore, this work illustrates that projections from the CEAm and CEAi converge into the caudal lateral LHA but diverge into the rostral tuberal LHA.

Mots clés

amygdala, hypocretin, lateral hypothalamus, melanin-concentrating hormone, tract tracing

Référence

Front Neurol. 2018 ;9:688