Mitophagy mechanisms and role in human diseases.
Fiche publication
Date publication
août 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUITTAUT Michaël
Tous les auteurs :
Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar V, Zhang J
Lien Pubmed
Résumé
Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.
Référence
Int J Biochem Cell Biol. 2014 Aug;53:127-33