Viral manipulation of STAT3: Evade, exploit, and injure.
Fiche publication
Date publication
mars 2018
Journal
PLoS pathogens
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas, Dr LUPBERGER Joachim
Tous les auteurs :
Roca Suarez AA, Van Renne N, Baumert TF, Lupberger J
Lien Pubmed
Résumé
Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.
Mots clés
Animals, Humans, Inflammation, etiology, STAT3 Transcription Factor, metabolism, Signal Transduction, Virus Diseases, metabolism, Viruses, pathogenicity
Référence
PLoS Pathog.. 2018 Mar;14(3):e1006839