Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2.
Fiche publication
Date publication
mars 2018
Journal
The Journal of organic chemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DESAUBRY Laurent
Tous les auteurs :
Abou-Hamdan H, Désaubry L
Lien Pubmed
Résumé
NVS-SM2, the first activator of pre-mRNA splicing, displays remarkable pharmacological in vivo activities in models of spinal muscular atrophy. Herein we describe an improved approach to the synthesis of this compound, which features a convenient introduction of sterically encumbered amine moiety onto a fluoropyridazine intermediate.
Mots clés
Benzene, chemical synthesis, Chemistry Techniques, Synthetic, Piperidines, chemical synthesis, Pyrazoles, chemical synthesis, Pyridazines, chemical synthesis, RNA Splicing, drug effects
Référence
J. Org. Chem.. 2018 Mar 2;83(5):2954-2958