Pregnancy After Tubal Sterilization in a Woman Treated with Biologics for Severe Psoriasis.
Fiche publication
Date publication
mars 2018
Journal
Dermatology and therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François, Dr NARDIN Charlée
Tous les auteurs :
Nardin C, Colas M, Curie V, Pelletier F, Puzenat E, Aubin F
Lien Pubmed
Résumé
Little is known about whether immunosuppressed patients mount the immunological response necessary to ensure tubal occlusion. Theoretical concern for non-occlusion has limited the use of hysteroscopic sterilization in patients on immunosuppressive therapies. The effects of tumor necrosis factor-alpha (TNF-α) blockers and interleukin (IL)-17 inhibitors on contraception and pregnancy for patients with psoriasis are poorly documented. We report a case of pregnancy that ended in miscarriage in a patient treated first with TNF-α and then with IL-17 inhibitors for severe psoriasis after tubal sterilization with micro-inserts. Our observation suggests that the efficacy of tubal sterilization by micro-inserts may be impaired by these two biologics and that the risk of miscarriage may be increased in women with psoriasis treated with secukinumab.
Mots clés
Biologics, Pregnancy, Psoriasis, Sterilization
Référence
Dermatol Ther (Heidelb). 2018 Mar 9;: