Hippocampal Sparing During Craniospinal Irradiation: What Did We Learn About the Incidence of Perihippocampus Metastases?
Fiche publication
Date publication
mars 2018
Journal
International journal of radiation oncology, biology, physics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BERNIER-CHASTAGNER Valérie, Pr NOEL Georges
Tous les auteurs :
Padovani L, Chapon F, André N, Boucekine M, Geoffray A, Bourdeau F, Masliah-Planchon J, Claude L, Huchet A, Laprie A, Supiot S, Coche-Dequéant B, Kerr C, Alapetite C, Leseur J, Nguyen T, Chapet S, Bernier V, Bondiau PY, Noel G, Habrand JL, Bolle S, Doz F, Dufour C, Muracciole X, Carrie C
Lien Pubmed
Résumé
To identify the incidence of patients with perihippocampal metastases to assess the risk of brain relapse when sparing the hippocampal area. Medulloblastoma (MB) represents 20% of pediatric brain tumors. For high-risk MB patients, the 3- to 5-year event-free survival rate has recently improved from 50% to >76%. Many survivors, however, experience neurocognitive side effects. Several retrospective studies of patients receiving whole brain irradiation (WBI) have suggested a relationship between the radiation dose to the hippocampus and neurocognitive decline. The hippocampal avoidance-WBI (HA-WBI) approach could partially reduce neurocognitive impairment in children treated for high-risk MB.
Mots clés
Adolescent, Brain Neoplasms, diagnostic imaging, Cerebellar Neoplasms, diagnostic imaging, Child, Child, Preschool, Craniospinal Irradiation, methods, Female, Hippocampus, diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Medulloblastoma, diagnostic imaging, Neurocognitive Disorders, etiology, Organ Sparing Treatments, methods, Progression-Free Survival, Retrospective Studies, Survival Rate, trends
Référence
Int. J. Radiat. Oncol. Biol. Phys.. 2018 Mar 15;100(4):980-986