Design of Protein-Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells.
Fiche publication
Date publication
mars 2018
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BEGIN-COLIN Sylvie, Dr HARLEPP Sébastien, Dr MERTZ Damien
Tous les auteurs :
Fiegel V, Harlepp S, Begin-Colin S, Begin D, Mertz D
Lien Pubmed
Résumé
One key challenge in the fields of nanomedicine and tissue engineering is the design of theranostic nanoplatforms able to monitor their therapeutic effect by imaging. Among current developed nano-objects, carbon nanotubes (CNTs) were found suitable to combine imaging, photothermal therapy, and to be loaded with hydrophobic drugs. However, a main problem is their resulting low hydrophilicity. To face this problem, an innovative method is developed here, which consists in loading the surface of carbon nanotubes (CNTs) with drugs followed by a protein coating around them. The originality of this method relies on first covering CNTs with a sacrificial template mesoporous silica (MS) shell grafted with isobutyramide (IBAM) binders on which a protein nanofilm is strongly adhered through IBAM-mediated physical cross-linking. This concept is first demonstrated without drugs, and is further improved with the suitable loading of hydrophobic drugs, curcumin (CUR) and camptothecin (CPT), which are retained between the CNTs and human serum albumin (HSA) layer. Such novel nanocomposites with favorable photothermal properties are very promising for theranostic systems, drug delivery, and phototherapy applications.
Mots clés
Amides, chemistry, Camptothecin, chemistry, Curcumin, chemistry, Drug Delivery Systems, Humans, Nanocomposites, chemistry, Nanomedicine, Nanotubes, Carbon, chemistry, Phototherapy, methods, Proteins, chemistry, Serum Albumin, Human, metabolism, Silicon Dioxide, chemistry, Theranostic Nanomedicine
Référence
Chemistry. 2018 Mar 26;24(18):4662-4670