Magnetic resonance imaging follow-up of progressive hippocampal changes in a mouse model of mesial temporal lobe epilepsy.
Fiche publication
Date publication
juin 2000
Journal
Epilepsia
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques
Tous les auteurs :
Bouilleret V, Nehlig A, Marescaux C, Namer IJ
Lien Pubmed
Résumé
Hippocampal sclerosis (HS) is the most frequent lesion found in mesial temporal lobe epilepsy (mTLE). MR imaging is considered to be the most sensitive and specific method to detect HS. Despite extensive studies performed on humans and except in a recent study, the morphologic pattern of HS is usually analyzed when the disease has already fully developed, thus not allowing any insight into the mapping of the progressive morphologic changes inducing the development of mTLE. We have recently characterized a model of mTLE that reproduces the unilateral pattern of HS, induced by intrahippocampal injection of low doses of kainate (KA) in mice.
Mots clés
Animals, Brain Diseases, chemically induced, Disease Models, Animal, Epilepsy, Temporal Lobe, chemically induced, Follow-Up Studies, Functional Laterality, physiology, Gadolinium, administration & dosage, Hippocampus, drug effects, Image Enhancement, Kainic Acid, administration & dosage, Magnetic Resonance Imaging, statistics & numerical data, Mice, Microinjections, Nerve Degeneration, chemically induced, Sclerosis, chemically induced, Seizures, chemically induced, Status Epilepticus, chemically induced
Référence
Epilepsia. 2000 Jun;41(6):642-50