Language functional neuro-imaging changes following focal left thalamic infarction.
Fiche publication
Date publication
septembre 2000
Journal
Neuroreport
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques
Tous les auteurs :
Metz-Lutz MN, Namer IJ, Gounot D, Kleitz C, Armspach JP, Kehrli P
Lien Pubmed
Résumé
The involvement of the left thalamus in language function has been largely demonstrated through the effects of thalamic lesion and/or stimulation upon language. However, the pathophysiological mechanisms underlying thalamic aphasias remain a matter of debate. We report here on changes in the pattern of brain activity in auditory word processing, verb generation and visual lexical decision in a patient who sustained left thalamic infarct following the surgery of intractable mesio-temporal epilepsy with left hippocampal sclerosis. To some extent, our findings exemplify the way the left thalamus brings on line the cortical networks involved in language processing, suggested in the term 'selective engagement'.
Mots clés
Aphasia, etiology, Brain Infarction, etiology, Epilepsy, pathology, Female, Functional Laterality, physiology, Humans, Language Tests, statistics & numerical data, Magnetic Resonance Imaging, Middle Aged, Postoperative Complications, etiology, Psychomotor Performance, physiology, Speech Perception, physiology, Temporal Lobe, pathology, Thalamic Diseases, etiology, Thalamus, pathology, Verbal Behavior, physiology
Référence
Neuroreport. 2000 Sep;11(13):2907-12