Magnetic resonance imaging in the study of the lithium-pilocarpine model of temporal lobe epilepsy in adult rats.
Fiche publication
Date publication
avril 2002
Journal
Epilepsia
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques
Tous les auteurs :
Roch C, Leroy C, Nehlig A, Namer IJ
Lien Pubmed
Résumé
In temporal lobe epilepsy, it remains to be clarified whether hippocampal sclerosis is the cause or the consequence of epilepsy. We studied the temporal evolution of the lesions in the lithium-pilocarpine model of epilepsy in the rat with magnetic resonance imaging (MRI) to determine the progressive morphologic changes occurring before the appearance of chronic epilepsy.
Mots clés
Animals, Behavior, Animal, Brain, pathology, Cell Count, Epilepsy, Temporal Lobe, chemically induced, Glial Fibrillary Acidic Protein, metabolism, Immunohistochemistry, Lithium, Magnetic Resonance Imaging, Male, Microtubule-Associated Proteins, metabolism, Muscarinic Agonists, Neurons, pathology, Pilocarpine, Rats, Rats, Sprague-Dawley
Référence
Epilepsia. 2002 Apr;43(4):325-35