Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model.
Fiche publication
Date publication
octobre 2002
Journal
Epilepsia
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques
Tous les auteurs :
Roch C, Leroy C, Nehlig A, Namer IJ
Lien Pubmed
Résumé
Patients with temporal lobe epilepsy (TLE) usually had an initial precipitating injury in early childhood. However, epilepsy does not develop in all children who have undergone an early insult. As in patients, the consequences of the lithium-pilocarpine-induced status epilepticus (SE) are age dependent, and only a subset of 21-day-old rats will develop epilepsy. Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of rats.
Mots clés
Age Factors, Animals, Brain Diseases, chemically induced, Cerebral Cortex, drug effects, Disease Models, Animal, Entorhinal Cortex, drug effects, Epilepsy, Temporal Lobe, chemically induced, Female, Lithium Chloride, pharmacology, Magnetic Resonance Imaging, statistics & numerical data, Male, Pilocarpine, pharmacology, Probability, Rats, Rats, Sprague-Dawley, Status Epilepticus, chemically induced
Référence
Epilepsia. 2002 Oct;43(10):1129-36