4-Halogeno-sydnones for fast strain promoted cycloaddition with bicyclo-[6.1.0]-nonyne.
Fiche publication
Date publication
août 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain
Tous les auteurs :
Plougastel L, Koniev O, Specklin S, Decuypere E, Creminon C, Buisson DA, Wagner A, Kolodych S, Taran F
Lien Pubmed
Résumé
New sydnone derivatives have been synthesized and screened for their capacity to undergo fast copper-free cycloaddition reaction with bicyclo-[6.1.0]-nonyne. The influences of substitution in positions N-3 and C-4 of sydnones have been particularly studied leading to the identification of highly reactive partners for bio-orthogonal ligation reactions.
Référence
Chem Commun (Camb). 2014 Aug 25;50(66):9376-8