In situ chemical behaviour of methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) in reconstructed human epidermis: a new approach to the cross-reactivity issue.
Fiche publication
Date publication
mars 2016
Journal
Contact dermatitis
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques
Tous les auteurs :
Debeuckelaere C, Moussallieh FM, Elbayed K, Namer IJ, Berl V, Giménez-Arnau E, Lepoittevin JP
Lien Pubmed
Résumé
Methylisothiazolinone (MI) [with methylchloroisothiazolinone (MCI) in a ratio of 1:3, a well-recognized allergenic preservative] was released as an individual preservative in the 2000s for industrial products and in 2005 for cosmetics. The high level of exposure to MI since then has provoked an epidemic of contact allergy to MI, and an increase in MI/MCI allergy. There are questions concerning the MI/MCI cross-reaction pattern.
Mots clés
Cross Reactions, Cysteine, chemistry, Epidermis, chemistry, Histidine, analogs & derivatives, Humans, Lysine, analogs & derivatives, Magnetic Resonance Spectroscopy, Sulfhydryl Compounds, chemistry, Thiazoles, chemistry
Référence
Contact Derm.. 2016 Mar;74(3):159-67