High-resolution magic angle spinning (1)H nuclear magnetic resonance spectroscopy metabolomics of hyperfunctioning parathyroid glands.
Fiche publication
Date publication
août 2016
Journal
Surgery
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques
Tous les auteurs :
Battini S, Imperiale A, Taïeb D, Elbayed K, Cicek AE, Sebag F, Brunaud L, Namer IJ
Lien Pubmed
Résumé
Primary hyperparathyroidism (PHPT) may be related to a single gland disease or multiglandular disease, which requires specific treatments. At present, an operation is the only curative treatment for PHPT. Currently, there are no biomarkers available to identify these 2 entities (single vs. multiple gland disease). The aims of the present study were to compare (1) the tissue metabolomics profiles between PHPT and renal hyperparathyroidism (secondary and tertiary) and (2) single gland disease with multiglandular disease in PHPT using metabolomics analysis.
Mots clés
Adult, Aged, Female, Humans, Hyperparathyroidism, Primary, diagnosis, Hyperparathyroidism, Secondary, diagnosis, Magnetic Resonance Spectroscopy, Male, Metabolomics, Middle Aged, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies
Référence
Surgery. 2016 Aug;160(2):384-94