O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) uptake in insulinoma: first results from a xenograft mouse model and from human.
Fiche publication
Date publication
juillet 2017
Journal
Nuclear medicine and biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BACHELLIER Philippe, Dr BRASSE David, Pr LAQUERRIERE Patrice, Pr NAMER Izzie-Jacques
Tous les auteurs :
Imperiale A, Boisson F, Kreutter G, Goichot B, Namer IJ, Bachellier P, Laquerriere P, Kessler L, Marchand P, Brasse D
Lien Pubmed
Résumé
Herein we have evaluated the uptake of O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) in insulinoma in comparison with those of 6-(18)F-fluoro-3,4-dihydroxy-l-phenylalanine ((18)F-FDOPA) providing first data from both murine xenograft model and one patient with proved endogenous hyperinsulinemic hypoglycemia.
Mots clés
(18)F-FDOPA, (18)F-FET, Insulinoma, RIN-m5F, Small animal, microPET
Référence
Nucl. Med. Biol.. 2017 Jul;53:21-28