Impact of real-time metabolomics in liver transplantation: Graft evaluation and donor-recipient matching.
Fiche publication
Date publication
décembre 2017
Journal
Journal of hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BACHELLIER Philippe, Pr NAMER Izzie-Jacques
Tous les auteurs :
Faitot F, Besch C, Battini S, Ruhland E, Onea M, Addeo P, Woehl-Jaeglé ML, Ellero B, Bachellier P, Namer IJ
Lien Pubmed
Résumé
There is an emerging need to assess the metabolic state of liver allografts especially in the novel setting of machine perfusion preservation and donor in cardiac death (DCD) grafts. High-resolution magic-angle-spinning nuclear magnetic resonance (HR-MAS-NMR) could be a useful tool in this setting as it can extemporaneously provide untargeted metabolic profiling. The purpose of this study was to evaluate the potential value of HR-MAS-NMR metabolomic analysis of back-table biopsies for the prediction of early allograft dysfunction (EAD) and donor-recipient matching.
Mots clés
Early allograft dysfunction, Lactate, Liver transplantation, Metabolomics
Référence
J. Hepatol.. 2017 Dec 2;: