Transient postnatal over nutrition induces long-term alterations in cardiac NLRP3-inflammasome pathway.
Fiche publication
Date publication
avril 2018
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VERGELY Catherine
Tous les auteurs :
Siddeek B, Li N, Mauduit C, Chehade H, Rigal E, Tolsa JF, Armengaud JB, Yzydorczyk C, Benahmed M, Vergely C, Simeoni U
Lien Pubmed
Résumé
The prevalence of obesity is increasing worldwide at an alarming rate. Altered early nutrition, in particular postnatal overfeeding (PNOF), is a risk factor for impaired cardiac function in adulthood. In the understanding of the initiation or progression of heart diseases, NLRP3 inflammasome and non-coding RNAs have been proposed as key players. In this context, the aim of this study was to decipher the role of NLRP3 inflammasome and its post transcriptional control by micro-RNAs in the regulation of cardiac metabolic function induced by PNOF in mice.
Mots clés
Cardiac dysfunctions, Inflammasome, Micro-RNAs, Nutrition
Référence
Nutr Metab Cardiovasc Dis. 2018 Apr 14;: