Unexpected adverse effect of metyrapone: a case report.
Fiche publication
Date publication
avril 2018
Journal
Clinical endocrinology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PETIT Jean-Michel, Pr VERGES Bruno
Tous les auteurs :
Rouland A, Nguyen A, Fourmont C, Lapray M, Vergès B, Petit JM, Bouillet B
Lien Pubmed
Résumé
Hypercortisolism, or Cushing's syndrome, is a disease which can be treated surgically or with medications such as mitotane, ketoconazole or metyrapone. However, the use of metyrapone is not common, and the adverse effects are not well known. A metyrapone overdose is usually associated with gastro-intestinal symptoms and signs of adrenal failure. To our knowledge, no other side effects have been reported in connection with an ingestion of high doses of metyrapone. This article is protected by copyright. All rights reserved.
Mots clés
hypercortisolism, metyrapone, rhabdomyolysis
Référence
Clin. Endocrinol. (Oxf). 2018 Apr 19;: