HIV transmission from infected CD4+ T cells to allogenic T and dendritic cells is inhibited by broadly neutralizing antibodies.
Fiche publication
Date publication
avril 2018
Journal
AIDS (London, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak, Dr SALOME Nathalie
Tous les auteurs :
Ducloy C, Su B, Mayr L, Klingler J, Decoville T, Schmidt S, Laumond G, Salomé N, Bahram S, Moog C
Lien Pubmed
Résumé
In the semen, both free virus and infected cells are able to establish HIV infection during sexual intercourse. An efficient vaccine should, therefore, inhibit both infectious states. The aim of this study was to analyze the capacity of broadly neutralizing antibodies (bNAbs) to inhibit HIV transmission by the infected cells.
Référence
AIDS. 2018 Apr 19;: