Regulation of primary-microRNA processing.
Fiche publication
Date publication
avril 2018
Journal
FEBS letters
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PFEFFER Sébastien
Tous les auteurs :
Creugny A, Fender A, Pfeffer S
Lien Pubmed
Résumé
MicroRNAs (miRNAs) are evolutionarily conserved small regulatory RNAs that participate in the fine-tuning of many, if not all, fundamental biological processes. Molecular mechanisms involved in miRNA biogenesis and mode of action have been elucidated in the past two decades. Similar to many cellular pathways, miRNA processing and function can be globally or specifically regulated at several levels and by numerous proteins and RNAs. Given their role as fine-tuning molecules, it is essential for miRNA expression to be tightly regulated in order to maintain cellular homeostasis. Here, we review our current knowledge of the first step of their maturation occurring in the nucleus and how it can be specifically and dynamically modulated. This article is protected by copyright. All rights reserved.
Mots clés
Drosha, biogenesis, microRNA, regulation
Référence
FEBS Lett.. 2018 Apr 23;: