Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.
Fiche publication
Date publication
mai 2018
Journal
MedChemComm
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CIANFERANI Sarah, Dr WAGNER Alain, Dr KOLODYCH Sergii, Dr KONIEV Sasha
Tous les auteurs :
Koniev O, Dovgan I, Renoux B, Ehkirch A, Eberova J, Cianférani S, Kolodych S, Papot S, Wagner A
Lien Pubmed
Résumé
The reduction-rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody-drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its application in the preparation of potent and selective ADCs.
Référence
Medchemcomm. 2018 May 1;9(5):827-830