Merkel cell carcinomas infiltrated with CD33 myeloid cells and CD8 T cells are associated with improved outcome.
Fiche publication
Date publication
mai 2018
Journal
Journal of the American Academy of Dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François
Tous les auteurs :
Kervarrec T, Gaboriaud P, Berthon P, Zaragoza J, Schrama D, Houben R, Le Corre Y, Hainaut-Wierzbicka E, Aubin F, Bens G, Domenech J, Guyétant S, Touzé A, Samimi M
Lien Pubmed
Résumé
Merkel cell carcinoma (MCC) is a rare tumor of the skin that has an aggressive behavior. Immunity is the main regulator of MCC development, and many interactions between lymphocytes and tumor cells have been proven. However, the impact of tumor-infiltrating myeloid cells needs better characterization.
Mots clés
CD33, Merkel cell carcinoma, PD-L1, immune infiltrate, macrophages, myeloid cells
Référence
J. Am. Acad. Dermatol.. 2018 May;78(5):973-982.e8