Differentiating Merkel cell carcinoma of lymph nodes without a detectable primary skin tumor from other metastatic neuroendocrine carcinomas: The ELECTHIP criteria.
Fiche publication
Date publication
mai 2018
Journal
Journal of the American Academy of Dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AUBIN François
Tous les auteurs :
Kervarrec T, Zaragoza J, Gaboriaud P, Le Gouge A, Beby-Defaux A, Le Corre Y, Hainaut-Wierzbicka E, Aubin F, Bens G, Michenet P, Maillard H, Touzé A, Samimi M, Guyétant S
Lien Pubmed
Résumé
Merkel cell carcinoma (MCC) can present as a cutaneous tumor or a lymph node metastasis without a primary tumor. MCC presenting without a primary tumor (MCCWOPT) can be misinterpreted on histologic examination as lymph node metastasis (LNM) from another neuroendocrine carcinoma (LNMNEC). However, this distinction is crucial for therapeutic management.
Mots clés
CK20, MCPyV, Merkel cell carcinoma, TTF-1, differential diagnosis, lymph nodes, metastasis, neuroendocrine carcinoma
Référence
J. Am. Acad. Dermatol.. 2018 May;78(5):964-972.e3