A role for fumarate hydratase in mediating oxidative effects of galectin-3 in human cardiac fibroblasts.
Fiche publication
Date publication
mai 2018
Journal
International journal of cardiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ROSSIGNOL Patrick
Tous les auteurs :
Ibarrola J, Sádaba R, Garcia-Peña A, Arrieta V, Martinez-Martinez E, Alvarez V, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Cachofeiro V, Fay R, Rossignol P, López-Andrés N
Lien Pubmed
Résumé
Galectin-3 (Gal-3), a β-galactoside-binding lectin involved in cardiac inflammation and fibrosis, could regulate oxidative stress, although the mechanisms have not been elucidated. We herein investigated the changes in oxidative stress-related mediators induced by Gal-3 in human cardiac fibroblasts and in pathological animal and human models of cardiac diseases.
Mots clés
Aortic stenosis, Fibroblasts, Fumarate hydratase, Galectin-3
Référence
Int. J. Cardiol.. 2018 May 1;258:217-223