Dental pulp stem cell-derived conditioned medium: an attractive alternative for regenerative therapy.
Fiche publication
Date publication
août 2018
Journal
Tissue engineering. Part B, Reviews
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MENU Patrick
Tous les auteurs :
Kichenbrand C, Velot É, Menu P, Moby V
Lien Pubmed
Résumé
Mesenchymal stem cells have a lot of potential in regenerative medicine and mesenchymal stem cell-based therapies are currently explored in numerous research fields. Among these cells, deciduous or permanent dental pulp-mesenchymal stem cells represent a promising option in tissue engineering. This expectation is based on their capacity to self-renew, to repair various damaged tissues and organs due to their multipotency, as well as their ability to modulate immune system. They present other advantages such as the harvesting by a simple, painless and non-invasive procedure and the absence of ethical considerations. The role played by these cells in the reparative process is mainly attributed to paracrine mechanisms mediated by their secreted factors, namely the secretome. The secreted factors can be found in the cell culture medium, called conditioned medium. Moreover, conditioned medium presents many advantages compared to cells such as possible use in allogeneic therapies. This mini review aims at investigating the therapeutic use of dental pulp mesenchymal stem cell-derived conditioned medium, in order to develop cell-free therapies. The analysis of the available literature illustrates its massive panel of potential applications: mainly reduction of inflammation, promotion of angiogenesis and neurogenesis, reduction of stroke or ischemia, and organ regeneration. Furthermore, studies often highlight its superiority over the other sources of conditioned medium derived from other stem cells for the same applications. Dental pulp mesenchymal stem cell-derived conditioned medium is an attractive non-invasive and acellular tool for therapeutic approaches in regenerative medicine. This promising novel approach should be further explored for clinical applications.
Mots clés
conditioned medium, dental pulp, mesenchymal stem cells, regenerative medicine, secretome
Référence
Tissue Eng Part B Rev. 2018 Aug 29;: