Monte Carlo simulations guided by imaging to predict the in vitro ranking of radiosensitizing nanoparticles.
Fiche publication
Journal
International journal of nanomedicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BARBERI-HEYOB Muriel, Pr BASTOGNE Thierry, Dr PINEL Sophie, Dr RETIF Paul
Tous les auteurs :
Retif P, Reinhard A, Paquot H, Jouan-Hureaux V, Chateau A, Sancey L, Barberi-Heyob M, Pinel S, Bastogne T
Lien Pubmed
Résumé
This article addresses the in silico-in vitro prediction issue of organometallic nanoparticles (NPs)-based radiosensitization enhancement. The goal was to carry out computational experiments to quickly identify efficient nanostructures and then to preferentially select the most promising ones for the subsequent in vivo studies. To this aim, this interdisciplinary article introduces a new theoretical Monte Carlo computational ranking method and tests it using 3 different organometallic NPs in terms of size and composition. While the ranking predicted in a classical theoretical scenario did not fit the reference results at all, in contrast, we showed for the first time how our accelerated in silico virtual screening method, based on basic in vitro experimental data (which takes into account the NPs cell biodistribution), was able to predict a relevant ranking in accordance with in vitro clonogenic efficiency. This corroborates the pertinence of such a prior ranking method that could speed up the preclinical development of NPs in radiation therapy.
Mots clés
Computer Simulation, Glioblastoma, diagnostic imaging, Humans, In Vitro Techniques, Microscopy, Electron, Transmission, Monte Carlo Method, Nanoparticles, administration & dosage, Nanostructures, chemistry, Radiation-Sensitizing Agents, pharmacokinetics, Tissue Distribution, Tumor Cells, Cultured
Référence
Int J Nanomedicine. ;11:6169-6179