Essential role of ATP6AP2 enrichment in caveolae/lipid raft microdomains for the induction of neuronal differentiation of stem cells.
Fiche publication
Date publication
mai 2018
Journal
Stem cell research & therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr QUILLIOT Didier
Tous les auteurs :
Makdissy N, Haddad K, AlBacha JD, Chaker D, Ismail B, Azar A, Oreibi G, Ayoub D, Achkar I, Quilliot D, Fajloun Z
Lien Pubmed
Résumé
The subcellular distribution of prorenin receptor and adaptor protein ATP6AP2 may affect neurogenesis. In this study, we hypothesized that ATP6AP2 expression and subcellular relocalization from caveolae/lipid raft microdomains (CLR-Ms) to intracellular sites may correlate with neuronal differentiation (Neu-Dif) of adipose-derived mesenchymal stem cells (ADSCs).
Mots clés
ATP6AP2, Caveolae, Caveolin, Exosomes, Flotillin, Lipid rafts, Neural differentiation, Renin, Stem cells, Wnt signaling
Référence
Stem Cell Res Ther. 2018 May 11;9(1):132