Neutrophils recruited by leukotriene B4 induce features of plaque destabilization during endotoxemia.
Fiche publication
Date publication
mai 2018
Journal
Cardiovascular research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VONESCH Jean-Luc
Tous les auteurs :
Mawhin MA, Tilly P, Zirka G, Charles AL, Slimani F, Vonesch JL, Michel JB, Bäck M, Norel X, Fabre JE
Lien Pubmed
Résumé
Both leukotrienes and neutrophils have been linked to plaque destabilization. Despite being evoked, the role of leukotriene B4 on neutrophil recruitment to plaques and the concomitant effects of these two actors on plaque stability remain to be proven. Since both actors are elicited during endotoxemia, a condition associated with the risk of cardiovascular events, we investigated whether endotoxemia promotes leukotriene B4-mediated neutrophil infiltration in plaques and explored the roles of leukotriene B4 and neutrophils in plaque destabilization.
Référence
Cardiovasc. Res.. 2018 May 24;: