A multi-scale analysis of bull sperm methylome revealed both species peculiarities and conserved tissue-specific features.
Fiche publication
Date publication
mai 2018
Journal
BMC genomics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WEBER Mickaël
Tous les auteurs :
Perrier JP, Sellem E, Prézelin A, Gasselin M, Jouneau L, Piumi F, Al Adhami H, Weber M, Fritz S, Boichard D, Le Danvic C, Schibler L, Jammes H, Kiefer H
Lien Pubmed
Résumé
Spermatozoa have a remarkable epigenome in line with their degree of specialization, their unique nature and different requirements for successful fertilization. Accordingly, perturbations in the establishment of DNA methylation patterns during male germ cell differentiation have been associated with infertility in several species. While bull semen is widely used in artificial insemination, the literature describing DNA methylation in bull spermatozoa is still scarce. The purpose of this study was therefore to characterize the bull sperm methylome relative to both bovine somatic cells and the sperm of other mammals through a multiscale analysis.
Mots clés
Cattle, DNA methylation, Satellite repeats, Sperm
Référence
BMC Genomics. 2018 May 29;19(1):404