PET imaging of Ga-NODAGA-RGD, as compared with F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma.
Fiche publication
Date publication
juin 2018
Journal
EJNMMI research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles, Pr MARIE Pierre-Yves, Dr PINEL Sophie
Tous les auteurs :
Isal S, Pierson J, Imbert L, Clement A, Collet C, Pinel S, Veran N, Reinhard A, Poussier S, Gauchotte G, Frezier S, Karcher G, Marie PY, Maskali F
Lien Pubmed
Résumé
Tracers triggering αvβ3 integrins, such as certain RGD-containing peptides, were found promising in previous pilot studies characterizing high-grade gliomas. However, only limited comparisons have been performed with current PET tracers. This study aimed at comparing the biodistribution of F-fluorodeoxyglucose (F-FDG) with that of Ga-NODAGA-RGD, an easily synthesized monomeric RGD compound with rapid kinetics, in two different rodent models of engrafted human glioblastoma.
Mots clés
18F-FDG, 68Ga-NODAGA-RGD, Glioblastoma, PET, αvβ3 integrin
Référence
EJNMMI Res. 2018 Jun 15;8(1):51