Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor.
Fiche publication
Date publication
juin 2018
Journal
Stem cell research & therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr QUILLIOT Didier
Tous les auteurs :
Chaker D, Mouawad C, Azar A, Quilliot D, Achkar I, Fajloun Z, Makdissy N
Lien Pubmed
Résumé
Human adipose-derived mesenchymal stem cells (hADSCs) are promising cells that may promote hepatocyte differentiation (Hep-Dif) and improve liver function, but the involvement of Cdc42, a key small RhoGTPase which plays a crucial role in aging, is still not well established. We hypothesized that the inhibition of Cdc42 may rescue the hepatogenic potential of hADSCs derived from aged donors.
Mots clés
Adipose derived mesenchymal stem cells, Aging, Cdc42, Exosomes release, Hepatocyte differentiation, MAPK, ML141, PI3K, Wnt, miR122
Référence
Stem Cell Res Ther. 2018 Jun 19;9(1):167