Gold(I)-coumarin-caffeine-based complexes as new potential anti-inflammatory and anticancer trackable agents.
Fiche publication
Date publication
septembre 2018
Journal
ChemMedChem
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BETTAIEB Ali, Pr PAUL Catherine
Tous les auteurs :
Trommenschlager A, Chotard F, Bertrand B, Amor S, Richard P, Bettaïeb A, Paul C, Connat JL, Le Gendre P, Bodio E
Lien Pubmed
Résumé
Three new gold(I)-coumarin-based trackable therapeutic complexes and two non-trackable analogues have been synthesized and fully characterized. They all display antiproliferative properties on several types of cancer cell lines including colon, breast, and prostate. Two complexes displayed significant anti-inflammatory effect, while one displayed a pro-inflammatory behaviour - highlighting the impact of the position of the fluorophore on the caffeine scaffold. Additionnally, the three coumarin derivatives could be vizualized in vitro by two-photons microscopy.
Mots clés
antiproliferation, bioinorganic chemistry, cancer, gold, theranostics
Référence
ChemMedChem. 2018 Sep 11;: