Epidemiology of Merkel Cell Carcinoma. A population-based study from 1985 to 2013, in Northeastern of France.
Fiche publication
Date publication
septembre 2018
Journal
International journal of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CRIBIER Bernard, Pr LIPSKER Dan, Pr MEYER Nicolas, Pr VELTEN Michel
Tous les auteurs :
Kieny A, Cribier B, Meyer N, Velten M, Jégu J, Lipsker D
Lien Pubmed
Résumé
Merkel Cell Carcinoma (MCC) is an aggressive skin cancer with an increasing incidence. Population-based epidemiologic data about MCC in France are rare. This study aims to describe the epidemiology of MCC in Bas-Rhin, Northeastern of France, between 1985 and 2013. Data were collected from the Bas-Rhin Cancer Registry. We measured age-adjusted incidence rates (per 100,000 person-years) and effect of age, sex and period of diagnosis on survival. The world age-standardized incidence rate was 0.17 and it quadrupled between 1985 and 2013. Cases (n=111) occurred mostly in women (60%) and in persons ≥ 70 years of age (74%). Incidence rates was close for men (0.18) and women (0.16) and was 25-time higher in people ≥ 70 years of age but incidence rate similarly increased between 1985 and 2013 in persons older and younger than 70 years. Net five-year survival was 48.5 %; female sex and younger age were positive predictors of survival. Given the low number of cases, incidence and survival data should be interpreted with caution. Incidence of MCC in Bas-Rhin quadrupled between 1985 and 2013. The highest incidence rate was observed in people ≥ 70 years. Better survival was associated with female sex and younger age. We hypothesize that MCC will still increase and be diagnosed in increasingly younger patients in next generations. This article is protected by copyright. All rights reserved.
Mots clés
Merkel Cell Carcinoma, cancer registry, epidemiology
Référence
Int. J. Cancer. 2018 Sep 8;: